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Comments: Multi-day, single-dose administration of 24 mg orally for HEC has not been studied No reduction in dose or dosing frequency in these patients is warranted. 15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. Zofran can be taken with or without food. Ondansetron every 4 hours for 3 doses during a safety and efficacy trial. 15 mg/kg/dose IV q4h x3 doses; Start: 30min before chemo; Max: 16 mg/dose. Four- and 8-mg doses of either ZOFRAN Oral Solution or ZOFRAN ODT Orally. Corresponding doses of ZOFRAN tablets, ZOFRAN ODT ® orally disintegrating tablets and ZOFRAN oral. 3 DOSAGE FORMS AND STRENGTHS ZOFRAN tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths: 4 mg – white tablet with “4” engraved on the other side. Drug Content Provided and Reviewed by IBM Micromedex® The dose of this medicine will be different for different patients. 15 mg/kg over 15 min administered 30 min before chemotherapy, then 4 and 8 hr after first dose; not to exceed 16 mg (32 mg no longer recommended because of increased risk of QT prolongation). ZOFRAN oral solution contains the inactive ingredients citric acid anhydrous, purified water, sodium benzoate, sodium citrate, sorbitol, and strawberry flavor. The following information includes only the average doses of this medicine 0. The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is 0. For those ages 4 to 11, patients should take a 4-mg tablet or rapidly disintegrating tablet or 5 mL of liquid three times per. Administration Instructions for ZOFRAN ODT Orally Disintegrating Tablets. Circulating drug also distributes into erythrocytes. ( 2) Patients with severe hepatic impairment: do not exceed a total daily dose of 8 mg. [10] [11] It can be given by mouth or by injection into a muscle or into a vein.. Caution: Dilution of Zofran Injection is required in adult and pediatric patients prior to administration Recommended dose: 0. Plasma protein binding of ondansetron as measured in vitro was 70% to 76% over the concentration range of 10 to 500 ng/mL. Do not take this medicine in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label. Administration Instructions for ZOFRAN ODT Orally Disintegrating Tablets Do not attempt to push ZOFRAN ODT tablets through the foil backing Take Zofran exactly as prescribed by your doctor. Dosage & Administration See full prescribing information for the recommended dosage in adults and pediatrics. These data were combined with sequential pharmacokinetics data from 41 surgery patients 1 month to 24 months of age, who received a single dose of 0. Each 5 mL of ZOFRAN oral solution contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron. Comments: Multi-day, single-dose administration of 24 mg orally for HEC has not been studied Your doctor may change the dosage and prescription of ZOFRAN to get you the best results possible. 8 mg – yellow tablet with “8” engraved on the other side Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. Dosage forms: TAB: 4 mg, 8 mg; SOL: 4 mg per 5 mL; INJ: various nausea/vomiting prevention, chemo-related [IV route, highly- or moderately-emetogenic chemo, 6 mo and older] Dose: 0. The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment Dosage in Hepatic Impairment In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use in Specific Populations (8. For patients ages 12 and older, the dosage is the same as for adults. Indications & Dosage Zofran coupons. Follow your doctor's orders or the directions on the label. Dosage: How Much Zofran ODT Should I Take? [9] It is also effective for treating gastroenteritis. Administration Instructions for Zofran ODT Orally Disintegrating Tablets. ZOFRAN is also indicated for the prevention of postoperative nausea and/or vomiting. Dosage in Hepatic Impairment In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use in Specific Populations (8. 15‑mg/kg per dose for 3 doses (maximum of 16 mg per dose). In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use in Specific Populations (8. The recommended dosage regimens for adult and pediatric patients are described in Table 1 and Table 2, respectively.