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Phasellus nec erat sit amet nibh pellentesque congue Ondansetron Alternatives Compared Ondansetron Vivitrol (naltrexone) Naltrexone Prescription only Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Benadryl (diphenhydramine) & naproxen: OTC meds to try to lessen nausea (in place of zofran) can include things like Dramamine (meclizine, dimenhydrinate ), like Benadryl ( diphenhydramine) or Zyrtec (dyphenhydramine, loratadine, cetirizine ), or like Zantac ( famotidine, ranitidine ). Haldol may also be used for purposes not listed in this medication guide. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery.

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